Enex Labs

Open Source Science

Archive for November, 2009

Almost Complete.

Posted by nxcng on November 27, 2009

It has been very fun building the lab and now it is nearing completion. I have order a good lot of lab apparatus which should be arriving within the next week, this includes vacuum pumps, Bunsen burners, hot plates with stir, balance, organic chem apparatus (distillation columns and adapters), latex tubing, centrifuge, chromatography columns, cell plates, oven. The equipment will all be inventoried, everything will be inventoried and presented on this blog. Initially i had thought that i might try to build equipment my self, such as blowing glass and the likes, but after research i found that my lab could not economically support both a glass blowing studio as well as any type of experimental activities. I am still open to creating equipment at home, and have plans to attempt to construct various equipment at a later date.

I still need a  good freezer!!!!!

In essence, the lab is approaching the final stages of development. It has changed a lot from my initial plan, all in good ways. It is now much larger and contains a plan for more versatility then the original “cell culture” program i had dreamed up. Once the equiptment is obtained and the final touches are put on the lab i will begin to plan and document the proceedings.

As for reagents and other chemicals / media, they have not yet been purchased or obtained in any way. This means that the lab will not be operational instantly, but that much work will have to be done to obtain via my own efforts, or through purchasing, the chemicals which will be needed.
By mid/early December i will have photos up of the completed lab and also fill out the rest of the description including the experimental goals of the lab… I will mention here that the lab will focus on some sort of nanotoxicology.

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Jig Saw Ren, Community Creation

Posted by nxcng on November 8, 2009

I have heard that in some communist systems it is valuable to have the workers live near where they work.
What is work any ways?

I would like to take a moment to think about individuals and their homes. Some people have shops for various things, each arrangement of objects within the house implies a function, a capacity (think kitchen). It is like a manufacturing entity, or any process entity. Many processing entities are private and rare,very large, and have a significant portion of the “necessary” amount of function for some process (does that make sense to you?).

Moving seemingly jarringly in context, why don’t’ local communities “create” more things in collaboration?
It seems that many forms of “creation” are competitive in some regards.
Any ways, our communities need more public processing systems, shops, labs, facilities, collaborative environments.
We need these environments, and we need to be able to access them for free. That’s the problem though…
To run any process “costs” something, and if you are not getting a “return” which is equal or better then the cost to run a process, then you cannot sustain. It doesn’t always have to be about profit, it can be about balance as well… However some say you must have profit to make balance.

Regardless, it is worth a communally inspired movement of effort to “self fund” such endeavors for the sake of experimentation, at least. What a good use of our time it would be if we did a bit of meeting with other people at a space surrounded by the capacity to create and not just dream. Of course all dreams need a source to come true, be it raw materials or silicon chips and magnetic pole patterns in metal, or vegetables to cook, sugar to add to a baked good, or a body to dance and the fuel to run it… All dreams need a physical form to come to be, all dreams have a cost. It is our tools and human will which allows us to shape that physical form in the shadow of our innovation.

But let us be shrewd in our undertakings and realize that we must look ahead with clarity.
For think of the hurdles that all endeavors encounter and create. Within the “DIY” movement there is much recipe, but to truly research and create is more challenging. To create something unique for ones own specific application require one to in essence be and engineer. Whether you engineer a dance, food, or some robot, it requires a rare skill that takes time to hone, it takes more then following a recipe. When groups are collaborating on projects there can be problems which arise and cause strife. With a limited amount of equipment, and time as well, use of a facility becomes a question of sharing. In essence the Do it with others creation labs will have a chance to epitomize the types of situations which all large systems of processing run into. Time, Cost, Man Power, Interest…. For in a do it with others lab, a collaborative endeavor has a chance to be more complex and in the end more interesting but simply because the facility is “open source” does not mean that the same problems of collaboration will not appear.

In any capacity, it is a great chance to learn to share and work together, to learn to be safe and push the limits of the “general societal” knowledge and function.

What happens when we start functioning for each other, and not for another whom gives us a return that we spend upon static entertainment?

Creating is entertaining!

We are creating a non profit organization here in Seattle called Jigsaw Renaissance, check it out at http://www.jigsawrenaissance.org/

-K

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Lab on a chip, sensory science.

Posted by nxcng on November 4, 2009

There is a very large range of new technologies coming to societies soon which we could get excited about. However  it is important to recognize that because these technologies are not yet mainstream that we are free to find out how they can become mainstream, and that is where we find innovation. This is a subtle and trivial aspect of industry growth… In simple we are still free to blaze a trail into these new industries using the novel features of our new technologies as access points to regions outside of where we have been able to access previously.

An object of considerable potential and importance which would do us well to focus upon with ever increasing attention is the design, theory and construction of mico/nano fluidic “lab on a chip” technologies.
The problems with bringing these lab on a chip technologies into mainstream use do not appear to revolve around problems of construction and design as much as they revolve around human throughput and cost. I have already witnessed working lab on a chip technologies used for a variety of problems. We are at a point where we can give the engineers the problem and some time and they can make something for us. I have seen enough to believe that what is needed for lab on a chip to take off is a standardized library of chip systems to perform exact functions. Once we can standardize this we can make efficient strides in creating an industry capable of producing at an economic rate the products we desire.

The market is very ripe i believe.

One pathway to profit is for investors to choose a single design and invest in heavy production of that. For there are many labs throughout the world studying microfluidics and nanofluidics, lab on a chip systems. However, we must question if all of these labs share a standardized method for the production of specific functions? or do they instead design their own systems for specific and unique goals?
What i have seen is that most labs spend their time improving Lab on Chip devices and creating better systems.

We are playing with something that we have a good enough understanding of to create what we imagine. However our imagination has not yet settled into a standard, but it is fast approaching. Soon the time will be ripe for a standardized function (lab on chip test) to be mass produced at an extremely cheap cost such that the effect had upon industry of relevance to the chip type will be swift.

Consider the hurdles. If we focus only on the medical application of Lab on Chip we can see that there is already a large industry of medical labs which perform many procedures for the medical industry. We must realize that any large scale introduction of lab on a chip technology is going to disrupt an already active industry. We need to consider what incentives we have to disrupt this industry before we can develop a plan to quickly bring lab on a chip to mainstream market.

First we have the private incentive which is purely profit. Any group which can obtain good returns on their lab on a chip investments is naturally inclined to have incentive to do so.
There are also many possible benefit incentives, whereby use of lab on a chip is able to increase the speed and efficiency of medical lab and in return the whole medical industry. With the ability to do more screening and testing for less money and in less time we are also able to obtain more data within a given field. This is very exciting, if you could imagine that people could get “lab work” done in a simple small clinic visits then you can have a very clear picture of the data available within a given area. In essence, one of the prime incentives for large groups to adopt lab on a chip technologies is that it will allow them access to more complete data sets.
This is all very speculative of course, and we say nothing about how it is that Lab on a Chip will actually go mainstream.
For that issue i firmly believe that the best course of action is for small lab on a chip foundries to spring up in hospitals and near small clinics which can produce and keep inventory of the actual “labs on a chip”. Thus, if a local clinic wants to do some special order lab work they can contact the local lab on a chip foundry and tell them what they need, whereby the technicians in that lab will look up the needed chip in a data base and fabricate it on the spot for use by the medical worker. Or, if the medical worker needs a standard chip for blood tests they can be relieved to know that the local lab has plenty of those stocked… The medical worker may even have some on hand in his office ready to use.

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